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and 4:00 a.m

Zaulyanov et al., 1999

The first tier used rule-based filters, including Lipinskis Rule of Five ( 1 violation) and Vebers bioavailability criteria (rotatable bonds 10, polar surface area 0.6) and synthetic accessibility score ( 1), cytochrome P450 inhibition (pIC50 5 kcal/mol)

9 The RTA capacity to block peroxyl radicals was later attributed to the liproxstatins quinaxoline ring
