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Although primarily known as a pro-inflammatory cytokine that binds to cell membrane receptors to potentiate intracellular signaling 45 , eNAMPT can also be taken up by cells such as neurons and increase NAD + synthesis 46

The addition of lipoic acid further increased improvements in both clinical symptoms and NCV

The available research has not demonstrated that B12 supplementation leads to significant reductions in body weight or body mass index (BMI) in people without deficiency