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NSAIDS These drugs are sometimes used to relieve the pain and fever associated with ME/CFS

Despite sufficient preclinical evidence, the clinical application of natural products still faces challenges such as low bioavailability, poor BBB penetration, and poor stability, emphasizing the need for further research

Qiu W, Gobinath A, Wen Y, Austin J, Galea LAM

In our study, we found that the apoptosis of GABAergic neurons induced by sulindac was also accompanied by autophagy, and 3-MA, an inhibitor of autophagy, not only significantly attenuated sulindac-induced autophagy in larval zebrafish neurons but also significantly reduced neuronal apoptosis