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Second, the intricate crosstalk between the Wnt/-catenin pathway and other oncogenic signaling pathways, such as JAK/STAT and PI3K/Akt, underscores the need for combination therapies that target multiple pathways simultaneously

The lack of mechanistic overlap also means you are not doubling up on the same side effects

coli were gated by the parameters of small angle scatter (FSC) and side scatter (SSC), which characterize the size and granularity of cells, respectively
