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Future research should prioritise long-term outcomes in high-risk groups, comparisons of physiological versus pharmacological dosages in healthy subjects, cost-effectiveness analyses, and adherence monitoring to inform clinical guidelines for the management and prevention of B12 deficiency

Many of our GPs are unaware of the mental health aspect of B12 deficiency despite depression being one of the most common symptoms

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In these patients, parenteral (not by mouth) vitamin B12 is often used initially to ensure rapid absorption and resolution of the deficiency