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96 Studies have shown that this process is dependent on intracellular complement component (C) 5aR1 signaling, where C5a binds to receptors on the mitochondria, triggering ROS production and providing one of the necessary activation signals for inflammasome assembly and IL-1 secretion, especially in response to sterile inflammation induced by cholesterol crystal exposure

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Closing Thoughts Keep in mind that this article was written for informational purposes only, and is not intended to substitute or replace medical advice from your provider