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[DOI] [PubMed] [Google Scholar] 103.Smykiewicz K., Michalczewska A., Wierzejska N., Pach M., Nowak A., Fugas A., Chmielowiec Z., Partyka A., Dziedzic M., Dobrzaska J

Protonation at the 2-Position The lowest energy S2 and O2 protonated structures calculated for [s 2 Urd+H] + and [s 4 Urd+H] + , S2A S2 and O2A S4 both display C2- endo sugar puckering with anti nucleobase orientations and S2HO2HO3 and O2HO2HO3 dual hydrogen-bonding interactions, respectively, providing stability through an ion-dipole interaction, although both are calculated to be more than 20 kJ/mol (B3LYP) and 17 kJ/mol (MP2) less stable than the calculated ground conformers
[DOI] [PubMed] [Google Scholar] Grahn BH, Paterson PG, Gottschall-Pass KT, Zhang Z

Via the STAT3/GPX4 pathway, Thiostrepton (TST) induces ferroptosis in pancreatic cancer cells by reducing cellular iron overload, increasing ROS accumulation, raising MDA levels, and decreasing GSH-PX in these cells [138]
