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Un taux bas de vitamine B12 a rcemment t associ des cas de migraine chronique, et une homocystine leve, accompagne de cofacteurs dficients et danomalies du gne MTHFR (qui permet le passage de THF M-THF), a t lie la migraine avec aura, cause dune synthse dfaillante de mthionine, menant une accumulation dhomocystine, elle-mme gnratrice despces ractives de loxygne (causant un stress oxydatif)