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Altering the PUFA composition of dopaminergic neuronal membranes and co-treating with iron can synergistically amplify lipid peroxidation and trigger ferroptosis, which has been confirmed in LUHMES cell and mouse organotypic brain slice experiments (70)

Humanized mice with Gilbert syndrome gene promoter polymorphism (HuUGT1A1*28) [with knocked out from the mouse locus] were shown to have mildly elevated bilirubin levels and resistant to high-fat-diet-induced fatty liver disease and glucose intolerance [15]
