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Regarding delivery, most ferroptosis inducers are small-molecule compounds with diverse chemical properties and stability profiles, complicating their efficient delivery to target cells or tissues

These types of compounds would therefore be less likely to provide any therapeutic benefit

Recent findings from preclinical and clinical studies on IS have confirmed a bidirectional regulatory relationship between IS and gut microbiota dysbiosis, establishing the MGBA as a novel therapeutic target for ischemic stroke

Logically, local administration of antioxidant agents into the target site may be comparably superior, especially considering the increase in bioavailability and accurate targeting of the joint, bypassing the pharmacokinetic challenges and reducing exposure to inappropriate sites