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doi: 10.1038/nrmicro2910 46 WhiteT

Here, we show that impaired OGDHc activity (via ABHD11 inhibition) in human CD8 + lymphocytes has distinct effects from those observed in cancer cells, with the perturbed TCA cycle driving synthesis of unsaturated fatty acids, rather than the accumulation of 2-HG that inhibits 2-OGDDs

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coli , 14 rabbit reticulocyte, 49 and wheat germ systems, 50 extracts from a more diverse array of organisms are now used to exploit differences in post-translational modifications, metabolism, temperature optima, and other properties
