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Intranasal delivery bypasses first-pass degradation and adds a partial direct nose-to-brain route through olfactory and trigeminal pathways

For cells that are cycling, the presence of TET-mediated oxidation marks on one strand of CpG dinucleotides can promote passive DNA demethylation by preventing the methylation of the CpG on the opposite strand by DNMT1 after DNA replication, ( de novo methylation by DNMT3s during development

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