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Role of TGF- 1 Several studies have demonstrated that mechanical stretch can activate latent TGF- 1 present in the ECM and that this process is inhibited by antagonizing integrins and independent from protease activity, thus establishing a link between the mechanical force of vein wall stretch and activation of the biological molecule, TGF- 1 [117120]

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Huntingtons Disease Preclinical: The role of PACAP and the PAC 1 receptor in HD is not well understood, but with post-mortem human HD hippocampal samples showing specific decreases of PAC 1 without changes in VPAC 1 or VPAC 2 , its involvement and possible therapeutic efficacy have been explored in recent years by Xifr and colleagues in R6/1 mouse models of HD

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