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NAD+-Sirtuin1- PGC-1 improves mitochondrial function

(2004) Physical and functional interaction of growth hormone and insulin-like growth factor-I signaling elements

It also noted that as B12 deficiency increased, so too did insulin resistance

IGFBP-2 actions are linked to insulin, although only in cases of hyperinsulinemia [173] where it seems to play a role on adipocyte autocrine control [174]
