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Down syndrome (DS), caused by trisomy 21 (HSA21), is the most common genomic disorder of intellectual disability

4.3 Effect on neuro-developmental Throughout the developmental process, the brain exhibits heightened energy demands for synthesizing fundamental cellular structures, neurotransmitters, nucleic acids, proteins, carbohydrates, and lipids that are indispensable for neuronal growth and myelination (46, 47)

Plus, even when artificial sweeteners are used, the amount is kept minimal (like in the chocolate fudge, where it's less than 2%)

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