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Singh-TaylorAMoletJJiangSKorosiABoltonJLNoamYet al
Oxidative stress can lead to a decrease in osteoblast activity, an increase in osteoblast and osteoclast apoptosis and a decrease in the expression of key osteoblast differentiation markers such as COL1 A1 and ALP, ultimately hindering bone formation [65]
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ROS contribute to the activation of tyrosine kinases, protein kinase C, and the MAP kinase cascade, which determine the impairment of the cellular responses such as activation, proliferation and differentiation
