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Thirdly, patient heterogeneity in terms of genetic predisposition, renal immune cell infiltration patterns, and gut microbiota composition results in varying therapeutic responses
Experimental models demonstrate tubular and glomerular atrophy, developing fibrosis through TGF-1/Klotho/Wnt/-catenin signals [230], while the use of antioxidants NAC and MitoTEMPO shows a pronounced protective effect [216], confirming the therapeutic potential of interventions targeting oxidative stress
H., Martino C., Neth B
Younes A, Zhao S, Andreeff M
