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An approach like Chloes sounds very promising, he says

Therefore, targeting GST isozymes with specific inhibitors has been considered a potential therapeutic strategy for various diseases [150,151]

J Neurosci 23:75867591 Kopec K, Flood DG, Gasior M, McKenna BAW, Zuvich E, Schreiber J, Salvino JM, Durkin JT, Ator MA, Marino MJ (2010) Glycine transporter (GlyT1) inhibitors with reduced residence time increase prepulse inhibition without inducing hyperlocomotion in DBA/2 mice

Mitochondrial Tetrahydrofolate Interconversions One of the enzymes of folate metabolism, aldehyde dehydrogenase 1 family member L2, produces NADPH in the course of converting N 10 -formyltetrahydrofolate (10-formyl-THF) to tetrahydrofolate (THF) and CO 2