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The PHGDH inhibitors NCT-503 and CBR-5884 significantly suppress cell proliferation, with more potent effects under serine/glycine-deprived conditions (70)

The small molecule idebenone also has potential to treat Friedreichs ataxia

It is important to highlight that numerous studies in small groups of patients with kidney disease have demonstrated significant improvements in GFR following recombinant IGF-1 administration

However, it is crucial to acknowledge that current evidence is primarily derived from animal studies, and the analgesic effects of UA in humans remain to be clinically substantiated