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COPD and neuroinflammation crosstalk It is commonly believed that hypoxia, which is caused by inadequate airflow in COPD lungs, may affect the activity of enzymes that produce neurotransmitters like serotonin and dopamine [41, 42]
Association among extracellular superoxide dismutase genotype, plasma concentration, and comorbidity in the very old and centenarians
As early as more than ten years ago, some clinical studies reported a significant decrease in opioid receptor binding in supraspinal regions (e.g., posterior midbrain
12, 13, 14 Similarly, the class I PTC W1282X mutant exhibits compromised NBD1-NBD2 dimerization due to a partial deletion of NBD2, leading to folding defects and reduced activity (which would be proper of class II and III mutants)
