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In a comprehensive study investigating the impact of the estrogen metabolite 16-hydroxyestrone (16OHE1) on PASMCs, notable findings revealed its role in promoting increased NOX expression, leading to ROS production and subsequent proliferative responses in PASMCs, thereby facilitating vascular remodeling
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J Biol Chem 292:47664769 Cordes T, Lucas A, Divakaruni AS, Murphy AN, Cabrales P, Metallo CM (2020) Itaconate modulates tricarboxylic acid and redox metabolism to mitigate reperfusion injury
