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Given that fibrotic plaque is similar to mechanical abnormal structure, the appropriate micro-trauma by the injection may be beneficial to plaque remodeling and treatment similar to operative resection ( Verapamil As a calcium channel blocker used in the treatment of hypertension, verapamil plays an anti-fibrotic role by blocking the transportation of calcium into fibroblasts, inhibiting the transfer of proline into the matrix and stimulating the phenotype transformation of fibroblasts to produce collagenase ( Interferon-2b Interferon is a kind of low molecular weight protein characterized by modulating immune function in anti-proliferative or anti-neoplasm effects ( in vitro IFN2b could decrease fibroblasts proliferation, reduce the collagen synthesis and deposition, and increase collagenase activity in fibrotic plaques ( Corticosteroids Intralesional corticosteroids were used in the treatment of PD because of its property of inhibiting inflammation

5) While some associations have been observed, particularly with gout and renal diseases, evidence from Mendelian randomization studies did not consistently support a causal relationship between elevated serum urate levels and other metabolic or cardiovascular disorders

Omega-3 polyunsaturated fatty acid supplementation and non-alcoholic fatty liver disease: A me-ta-analysis of randomized controlled trials

Some people receive injections weekly, while others may need them less frequently