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demonstrated that, in diet-induced obese mice, the administration of a REV-ERB/ agonists reduced obesity by decreasing fat mass and significantly ameliorating dyslipidaemia and hyperglycemia, thus indicating a potential applicability for the treatment of metabolic diseases 136

Additionally, the diet reduces the expression of microglial activation markers (e.g., Iba1, CD11b), mitigating neuroinflammation, with its protective effects independent of amyloid- plaque reduction, thus offering new targets for intervening in early cognitive dysfunction (Di Lucente et al., 2024)

Protein oxidation in muscle foods: a comprehensive review