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Within the first 40 h, TAM and its metabolites were reduced by half after a single dose of TAM with TAM (9.9 h), 4-OH-TAM (15.8 h) and NMD-TAM (19.9 h) being cleared faster than END (33.2 h)

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Laliberte RE, Perregaux DG, Hoth LR, Rosner PJ, Jordan CK, Peese KM, Eggler JF, Dombroski MA, Geoghegan KF, Gabel CA: Glutathione s-transferase omega 1-1 is a target of cytokine release inhibitory drugs and may be responsible for their effect on interleukin-1beta posttranslational processing