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Description
The possibility to deliver drugs to the central nervous system (CNS) through nasal pathways remained unexplored until in 1991
The pathophysiological roles of key metabolites (e.g., succinate, lactate) and signaling pathways (e.g., TLR4/NF-B) are supported by extensive preclinical data and corroborative human biomarker studies (66, 78, 81)
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[DOI] [PMC free article] [PubMed] [Google Scholar] 150.Jurez-Lpez D., Morales-Ruiz E., Herrera-Ziga L.D., Gonzlez-Carrera Z., Cuevas-Reyes E., Corzo G., Schcolnik-Cabrera A., Villegas E
