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Despite extensive preclinical evidence, the clinical application of quercetin remains limited due to challenges related to poor bioavailability, rapid degradation, and the absence of standardized ocular formulations

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Moreover, the sympathetic hyperstimulation after exercise may, in ME/CFS patients with auto-antibodies (aAB) to vaso- and neuroregulatory G protein coupled receptors (GPCR), aggravate dysfunctional GPCR signaling and thus contribute to vascular and/or CNS dysfunctions (discussed below)

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plantarum and Pediococcus acidilactici for 30-days, showed total remission of 53.1% in the probiotic-treated compared to 28.1% in the placebo groups, respectively

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