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Despite extensive preclinical evidence, the clinical application of quercetin remains limited due to challenges related to poor bioavailability, rapid degradation, and the absence of standardized ocular formulations

Moreover, the sympathetic hyperstimulation after exercise may, in ME/CFS patients with auto-antibodies (aAB) to vaso- and neuroregulatory G protein coupled receptors (GPCR), aggravate dysfunctional GPCR signaling and thus contribute to vascular and/or CNS dysfunctions (discussed below)

plantarum and Pediococcus acidilactici for 30-days, showed total remission of 53.1% in the probiotic-treated compared to 28.1% in the placebo groups, respectively
