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Description
The ligandin (non-substrate) binding site of human Pi class glutathione transferase is located in the electrophile binding site (H-site)

Renal and hepatic effects: Long-term or high-dose use has been associated in case reports with adverse effects on kidney and liver function

Most current research-context subcutaneous protocols cite 300-500 mcg/day, but no published human pharmacokinetic study has formally evaluated the subcutaneous route

These include pain, swelling, itching, bruising, and redness
