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Subsequent studies also confirmed that DMB can improve certain diseases by reducing TMAO concentrations, such as allogenic gain-versus-host disease (Wu et al., 2020) and endothelial dysfunction (Roberts et al., 2018)
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demonstrated that acute activation of PDH by DCA competed for pyruvate and partially reduced its flux through malic enzyme, which led to normalization of the myocardial triglyceride pool and improved contractile function
