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Description
The mice were euthanized on day 38 after tumor implantation
Additionally, increased acetylcholinesterase (AChE) activity and inhibited butyrylcholinesterase (BuChE) activity were observed in the brain after plastic exposure (45)
The enhanced drug bioavailability caused by piperine is due to its potent inhibition of drug metabolism, being able to inhibit human P-glycoprotein and CYP3A4, while it interferes with UDP-glucose dehydrogenase and glucuronidation activities in liver
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