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Oxidative stress Oxidative stress, a concept introduced by Sies in 1985, arises when the endogenous antioxidant defense system of cells and tissues is unable to cope with a sudden or prolonged increase in ROS production, leading to the disruption of redox signaling and regulation, as well as molecular damage (Sies 1985, 2015

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[DOI] [PubMed] [Google Scholar] 116.Eftekharpour E., Fernyhough P

doi: 10.1093/brain/awae101 42 TaubeM