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Description

GSTs exhibit a wide intracellular distribution, being localized in mitochondria (GSTA1), cytosol (alpha, mu, pi, and zeta) and membrane-bound (MGST1) isoforms (Li et al., 2011)

But through glucuronidation, not only bilirubin is eliminated, but other complexes are eliminated: Bilirubin (from the breakdown of old red blood cells) Retinoids (vitamin A components) Estrogens and testosterone BPA and BPS Cortisol Certain fatty acids (DHA, oleic acid, linoleic acid) A large number of medications , including paracetamol (acetomiphen) Certain pesticides Polycyclic aromatic hydrocarbons (PAHs carcinogenic) Certain mold toxins Thyroid hormone (T3, T4) This explains why those diagnosed with Gilbert syndrome can present with other ailments