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In addition to its central role in generating over 95% of a cells energy through ATP, changes in mitochondrial morphology and function accompany lymphocyte differentiation and activation 21 , with mitochondria driving cytokine production 22 , thereby linking energy metabolic deficits in immune cells with chronic inflammation

38 , doi:10.1146/annurev.biophys.050708.133655 (2008)

Moreover, they secrete and activate MMPs to degrade the provisional ECM and release de novo ECM components [81]

Amassed fragmented HA during the stress and remodeling of adipose tissue demonstrates an announcement of danger-associated pattern molecule (DAMP), instigating CD44 to initiate inflammatory signaling pathways, such as NF-kB and MAPK