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Interestingly, it can take years for B12 stores to deplete to a point where a deficiency becomes apparent: Vitamin B12 deficiency affects multiple systems, and sequelae vary in severity from mild fatigue to severe neurologic impairment

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10.1007/s00401-013-1214-6 Acta Neuropathol

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The peptides were constructed in levorotatory conformation

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