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Tumour-associated neutrophils (TANs) can promote a hypoxic microenvironment and immunosuppression [226]

This can be expected to result in GTP depletion

2xL-Glutamine)

This substitution results in an alanine-to-valine change, leading to a significant reduction in the enzyme activity observed in vitro in both heterozygotes and homozygotes [67,108]
