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Besides, they can serve as a tight junction (TJ) modulator to trigger an intracellular signaling cascade, causing TJ disruption and actin cytoskeleton reorganization to form an intercellular "green channel" to help them to cross the blood-brain barrier (BBB) silently

6 suggests that two substitutions (N74S and R121S) give rise to structural changes that reorient the copper-coordinating side chains of H451 and H453

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Additionally, Figure 1 graphically illustrates the overall mechanisms of ferroptosis, complementing the tabular information and further facilitating understanding