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In a study in subjects with impaired glucose tolerance, arterial flow (a measure of endothelial function) was markedly decreased during fasting and after a glucose challenge

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TB-500 itself has not been studied in human trials, though its parent molecule (which isnt identical), thymosin beta-4, has progressed to Phase I trials for specific conditions in China

However, payers are increasingly scrutinizing compounded drug claims and may reimburse at the compounded drug rate rather than the brand-name rate
