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In humans, reduced stride length and walking capacity are strongly linked to mortality and morbidity 30

The term FODMAP stands for: F ermentable O ligosaccharides (fructans and galacto-oligosaccharides or GOS) D isaccharides (lactose) M onosaccharides (excess fructose) A nd P olyols (sorbitol and mannitol) These carbohydrates draw water into the digestive tract and produce gas when fermented by colonic bacteria

Side effects from nirogacestat were generally modest and included diarrhea and rash

In total, we trained COWAS models using UKB genotypes and protein abundance levels for 26,433 protein pairs, after normalizing and adjusting for standard covariates
