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Therefore, we need to explore the resistance mechanism of sorafenib and novel treatments against HCC, such as c-Met and downstream signaling pathway inhibitors ( Hepatocyte growth factor (HGF) and its high-affinity receptor, mesenchymal epithelial transition factor (c-Met), are closely related to the onset, progression and metastasis of multiple tumors

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GSH will largely be found in the reduced/GSH state, stored 8085% in the cytosol, 1015% in mitochondria, and another 1% in the endoplasmic reticulum