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NICE-approved weight management interventions include: Dietary and lifestyle modification first-line approach for all patients Orlistat licensed medication for obesity (BMI 30 or 28 with comorbidities) GLP-1 receptor agonists including semaglutide (Wegovy) per NICE TA875 and liraglutide (Saxenda) with restrictions per NICE TA664, for specific patient groups Bariatric surgery for severe obesity meeting strict criteria The NHS emphasises that sustainable weight loss requires behavioural change, nutritional education, and increased physical activity

In 2017, the authors of a review described it as well tolerated. A person using it does not need ongoing lab tests to monitor for adverse effects

This is because ice crystal formation and repeated freeze-thaw cycles can cause aggregation, denaturation, or structural disruption

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