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Toogood PL, Clauw DJ, Phadke S, Hoffman D

However, coffee enemas are extremely uncomfortable for patients when the rectum is full of fecal material

[DOI] [PubMed] [Google Scholar] 7.MacNee W
Experimental studies report activation of signaling mechanisms related to vascular remodeling, including Notch-associated pathways and endothelial cell activation in angiogenesis models [8]
