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Vitamin B12 can cause dermatitis, acne, and other skin-related conditions when taken in excess, according to a review in the American Journal of Clinical Dermatology
It is common for an intramuscular injection of vitamin C to sting during an injection, and afterward have redness, swelling and soreness at the injection site
Therefore, in patients with renal insufficiency (assessed by measurement of serum creatinine), serum holoTC concentrations may appear normal, and are no longer a useful biomarker to predict B12 status (Herrmann et al., 2005)
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