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Although both acetyl-l-carnitine and gabapentin provided significant pain relief, acetyl-l-carnitine (100 mg/kg, i.p., 14 days), but not gabapentin (70 mg/kg, i.p., 14 days), significantly prevented nerve fibre and myelin thickness loss and increased axonal neurofilament immunoreactivity [16]
Most notable, there were only few eligible RCTs included in this meta-analysis and most of them had a relatively modest number of participants
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 248 (2), R166R171
doi: 10.1016/j.metabol.2015.03.008
