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For instance, NR supplementation in preclinical studies has been shown to reduce chemotherapy-induced peripheral neuropathy, inhibit cancer metastasis, and, in some cases, enhance tumor-suppressive effects. A brief summary of these findings can be found below in the Appendix in Table 1, illustrating that NAD+ metabolism is complex and may be protective under certain conditions

This is mediated by the interaction of CD47 with the inhibitory macrophage receptor, SIRP (Signal regulatory protein alpha) [166]

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Individuals with certain autoimmune conditions may require special consideration