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The FDA and KMFDS approved a phase III, multicenter, randomized, double-blind, sham-procedure-controlled trial, conducted exclusively in South Korea [166] NCT 04745299, KCT0005954, which did not meet primarily efficacy outcomes [167], though long-term follow-up and safety reporting continues through 2026

1 Their basic structures consist of bicyclic skeletons, carboxylic acids, and keto groups at positions 3 and 4, respectively, which are necessary for their pharmacological activity 2,3 (Figure 1)

Several molecular mechanisms are involved in the association between ferroptosis and PF

When administered intravenously, glutathione bypasses the digestive tract, resulting in enhanced bioavailability and faster systemic benefits