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Description
Dopamine can be further converted into noradrenaline with the help of vitamin C, and this in turn can be metabolised to adrenaline by a methylation reaction (again dependent on SAM)
To partially compensate for this, patients are often given high systemic doses, which may increase brain exposure but also lead to significant off-target toxicity

But I hate when like people talk about this and then they're

However, this modification also disrupts CaM-KII binding (OLeary et al., 2011)
