extracellular glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis Detect Glutathione in cell samples with Intracellular glutathione (GSH) Detection Assay Kit (ab112132) GCEL Intracellular Glutathione Capsules |

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Supplementing with creatine (in animals) promotes T cells to better fight cancer and suppresses tumor growth.[ref] A study involving data from over 7,000 people found that a higher dietary creatine intake is associated with a lower relative risk of cancer.[ref] Clinical trials using creatine supplements in cancer patients: A meta-analysis of clinical trials involving cancer patients taking supplemental creatine showed that there were no safety issues, but there were also no significant benefits found for muscle strength or lean mass compared to placebo.[ref] Studies on how cancer cells can utilize creatine for energy under certain conditions: A cell-line study showed that colon cancer cells can use phosphocreatine through the creatine shuttle pathway as an energy production mechanism.[ref] In mice with cancer that has metastasized, the GATM enzyme for creatine synthesis is upregulated, and de novo synthesis of creatine is thought to increase cancer metastasis.[ref] In liver cancer metastasis, the GATM enzyme and creatine synthesis is also upregulated.[ref] Big picture for creatine and cancer: Overall, the research on creatine and cancer shows that it is dependent on context