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High-energy diets are now widely fed to farmed fish, which has led to a number of metabolic diseases, especially severe fat accumulation, developing in various fish species, leading to adverse effects on their growth and health ( Reference Wang, Liu and Tian 25 , Reference Du, Clouet and Huang 26 )
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NRF2 then translocates to the nucleus, where it binds to the antioxidant response element (ARE) and acts as a co-transcription factor for various proteins with antioxidant properties
