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B12
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Rarely, hypersensitivity reactions can occur, for instance, urticaria (hives) or other allergic-type reactions have been reported in isolated cases

In mice, a high-fat diet has also been shown to impair leptin signaling by attenuating STAT3 activation, thus contributing to leptin resistance [18].Leptin receptor activation engages intracellular proteins, such as protein tyrosine phosphatase1 B (PTP1B) and suppressor of cytokine signaling-3, that terminate receptor signaling

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Mood stabilization represents another potential benefit
