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Hydrolysis of cysteinylglycine and of cysteinylglycine S -conjugates formed from the -glutamyl transpeptidase-mediated degradation of GSH and GS-conjugates, respectively, is mediated by various dipeptidase activities, including the plasma membrane-bound ectoenzyme aminopeptidase N (Figure 1C), and cytosolic leucyl aminopeptidase (EC 3.4.11.1

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Synthetic mRNAs, which transiently express functional cystinosin, have demonstrated beneficial and sustained impacts on proximal tubular resorptive function, proteinuria, and kidney morphology in zebrafish after treatment [157]