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Together, these findings suggest that Rac1-containing l-EVs are initially transported to early endosomes and subsequently trafficked to late endosomes in recipient cells

Dasatinib has shown antifibrotic effects in keloid fibroblasts and xenotransplant keloid tissue in mice through the selective clearance of senescent cells and modulation of SASP, implying that dasatinib can be possibly used for senolytic treatment of keloids 15

RNA polymerase RNAP is an evolutionarily conserved enzyme that plays a vital role in both transcription initiation and RNA elongation, and is subject to diverse regulatory mechanisms mediated by multiple transcription factors

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